Nature

Single-case experimental designs: the importance of randomization and replication

Single-case experimental designs (SCEDs) involve repeat measurements of the dependent variable under different experimental conditions within a single case, for example, a patient or a classroom 1.
Nature

Mendelian randomization study revealed a gut microbiota-neuromuscular junction axis in myasthenia gravis

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by pathogenic antibodies directed against acetylcholine receptors (AChR), muscle-specific kinase (MUSK), lipoprotein-related ...
ascopubs.org

CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non–Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy

Phase Ib Study of Unesbulin (PTC596) Plus Dacarbazine for the Treatment of Locally Recurrent, Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma One hundred eighty-six patients were ...
ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...
Purdue University

Research Design and Ethics

Once you have determined your research question, the next step is to decide on a research design. As random assignment tends to be challenging in SoTL, most projects tend to fall into the ...