Nature

Astrocyte activation persists one year after TBI: a dynamic shift from inflammation to neurodegeneration

Traumatic brain injury (TBI) remains a leading cause of chronic neurological impairment, yet the cellular mechanisms underlying long-term neurodegeneration in TBI remain incompletely understood.
eLife

Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

Differentiation of induced pluripotent stem cells (iPSCs) toward neuronal lineages has enabled diverse cellular models of human neurodevelopment and related disorders. Here, we jointly profiled ...
Frontiers

Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes

The study utilized datasets from the GEO database, specifically GSE145989 and GSE127003, which include samples of lung cold ischemia and reperfusion following transplantation. Differential expressed ...
C&EN

iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Thanks to the plummeting costs of continuously evolving omics analytical platforms, ...
ahajournals.org

Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

Vein graft failure following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and ...
ahajournals.org

Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans

Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques is predictive for the risk of ...
PNAS

Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8–Aop–Dilp6 axis

The adipose tissue is a central hub of metabolic and endocrine regulation with a major impact on aging. We identify the conserved miRNA-processing enzyme Dicer-1 (Dcr-1) as a crucial regulator of ...
Scientific Research Publishing

Identification and Validation of Vascular-Associated Biomarkers for the Prognosis and Potential Pathogenesis of Hypertension Using Comprehensive Bioinformatics Methods ()

1 Department of Laboratory, Yangbi Yi Autonomous County People’s Hospital, Dali, China. 2 Department of Obstetrics and Gynecology, Yangbi Yi Autonomous County People’s Hospital, Dali, China. 3 ...
Nature

Upregulation of extracellular proteins in a mouse model of Alzheimer’s disease

Various risk factors of Alzheimer’s disease (AD) are known, such as advanced age, possession of certain genetic variants, accumulation of toxic amyloid-β (Aβ) peptides, and unhealthy lifestyle. An ...
eLife

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates

Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate protective humoral immunity. A detailed understanding of the cues controlling ASC differentiation is ...
GitHub

Preventing overlap of gene labels/names in cnetplot

I'm working on creating a cnetplot based off of a compareCluster enrichment result. I want to plot 5 GO Biological Processes as the individual categories with the corresponding genes connecting with ...